Certificate Reference
For continuity with the current catalog, this page links to laboratory documentation for a component or a closely related product. The linked certificate is a reference only and is not represented as the batch-specific COA for AICAR.
Overview
AICAR is a classic metabolic research tool used to probe cellular energy sensing. After entering cells it is converted to ZMP, an AMP-like metabolite that can activate AMPK and shift multiple pathways involved in glucose handling, lipid metabolism, mitochondrial function, and energy stress.
Research Reference: View compound profile on NIH PubChem
Research Focus
WHAT THIS FORMULA FEATURES
A well-known AMPK-pathway modulator with a broad literature base across metabolism, exercise biology, hypoxia, nucleotide synthesis, and cancer models. Importantly, AICAR can also produce AMPK-independent effects, so pathway attribution should be verified rather than assumed.
EXPECTED RESEARCH READOUTS
Researchers often measure AMPK and ACC phosphorylation, glucose uptake, fatty-acid oxidation, mitochondrial/energy-state markers, adipogenesis, and downstream transcriptional changes. Parallel AMPK-loss or inhibitor controls help distinguish AMPK-dependent from off-target effects.
Research endpoints described above reflect published or model-based scientific observations and are not guaranteed outcomes. This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
Formula: C9H14N4O5
Weight: 258.23 g/mol
CAS: 2627-69-2
PubChem CID: 17513
Classification: Nucleoside research compound (acadesine)
PHYSICAL PROPERTIES
Form: Lyophilized powder
Catalog strengths: 50 mg | 100 mg
Purity specification: ≥99% catalog specification; verify current batch COA
Storage: Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.
Testing: Batch documentation should be verified against the current lot before analytical use.
