Certificate Reference
For continuity with the current catalog, this page links to laboratory documentation for a component or a closely related product. The linked certificate is a reference only and is not represented as the batch-specific COA for IGF-1 LR3.
Overview
IGF-1 LR3 (Long R3 IGF-I) is an engineered insulin-like growth factor-I analog designed to reduce binding to IGF-binding proteins while retaining activity at the IGF-1 receptor. That lower IGFBP affinity makes it useful when researchers want a more freely bioavailable IGF signal than native IGF-1 in cell-growth and differentiation models.
Research Reference: View compound profile on NIH PubChem
Research Focus
WHAT THIS FORMULA FEATURES
The defining feature is reduced sequestration by IGF-binding proteins. In cultured fibroblasts and chondrocytes, Long R3 IGF-I has shown greater apparent potency than native IGF-I under conditions where endogenous IGFBPs limit activity. This makes it a useful comparator for separating receptor-driven IGF signaling from extracellular binding-protein regulation.
EXPECTED RESEARCH READOUTS
Typical research endpoints include IGF1R phosphorylation, PI3K-AKT and MAPK signaling, DNA synthesis, cell proliferation, protein synthesis, glucose uptake, and comparisons with native IGF-I in the presence or absence of IGFBPs. Effects are strongly cell-type and model dependent.
Research endpoints described above reflect published or model-based scientific observations and are not guaranteed outcomes. This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
CAS: 143045-27-6 | 946870-92-4
Classification: Long R3 IGF-1 protein analogue
PHYSICAL PROPERTIES
Form: Lyophilized powder
Catalog strengths: 0.1 mg | 1 mg
Purity specification: ≥99% catalog specification; verify current batch COA
Storage: Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.
Testing: Batch documentation should be verified against the current lot before analytical use.
