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Epithalon

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Epithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide — a chain of four amino acids — with the sequence Ala-Glu-Asp-Gly. It has a molecular weight of 390.34 g/mol and the formula C14H22N4O9 (CAS 307297-39-8). It was first synthesized in the 1990s, modeled on the amino acid composition of epithalamin, a peptide extract from the bovine pineal gland. Epithalon is among the smallest peptides studied in bioregulation research. Its sequence contains two acidic residues — glutamic acid and aspartic acid — giving the molecule a net negative charge at physiological pH. It appears as a white lyophilized powder, dissolves readily in water, and requires refrigerated storage. This product is strictly for research purposes only.

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Certificate of Analysis

Independent laboratory testing confirms purity and composition of this research peptide.

Endo Passed

99.350%
Purity
A2926023
Batch
August 2026
Date

View Certificate →

Overview

Epithalon (also spelled Epitalon or Epithalone) is a synthetic tetrapeptide — a chain of four amino acids — with the sequence Ala-Glu-Asp-Gly. Its molecular formula is C14H22N4O9, with a molecular weight of 390.34 g/mol (CAS 307297-39-8). It was first synthesized in the 1990s, based on the amino acid composition of epithalamin, a peptide extract derived from the bovine pineal gland.

As a tetrapeptide, Epithalon is one of the smallest biologically studied peptides. Its four-residue sequence — alanine, glutamic acid, aspartic acid, and glycine — gives it two acidic side chains, making the molecule negatively charged at physiological pH. It dissolves readily in water and appears as a white lyophilized powder in its research-grade form.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem

Key Characteristics

MOLECULAR PROFILE

Formula: C14H22N4O9

Weight: 390.34 g/mol

CAS: 307297-39-8

Structure: Ala-Glu-Asp-Gly

PHYSICAL PROPERTIES

Form: White lyophilized powder

Solubility: Readily dissolves in water

Origin: Synthetic version of epithalamin

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

Additional information

Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Peptide

Epithalon

Strength

10mg, 50mg

CAS Number

307297-39-8, 64082-79-7

PubChem CID

219042

Purity

≥99% (third-party HPLC and mass spectrometry verified)

Form

Lyophilized powder

Storage

Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.

Testing

Batch-specific COA included

Origin

Manufactured in the US

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