Certificate Reference
For continuity with the current catalog, this page links to laboratory documentation for a component or a closely related product. The linked certificate is a reference only and is not represented as the batch-specific COA for PNC-27.
Overview
PNC-27 is a chimeric peptide built from the HDM2-binding region of p53 joined to a membrane-penetrating sequence. Unlike many p53-derived peptides that depend on intracellular transcriptional effects, PNC-27 has been studied for a membrane-level mechanism involving HDM2 expressed on the surface of certain tumor cells.
Research Reference: View compound profile on NIH PubChem
Research Focus
WHAT THIS FORMULA FEATURES
Published cell and structural studies show PNC-27 binding to membrane-associated HDM2 and formation of transmembrane pores, with rapid membranolysis in susceptible tumor-cell models. The research interest is this unusual combination of molecular recognition and direct membrane disruption.
EXPECTED RESEARCH READOUTS
Common endpoints include surface HDM2 expression, PNC-27/HDM2 colocalization, LDH release, membrane-pore formation, cell viability, necrosis versus apoptosis markers, mitochondrial integrity, and selectivity comparisons with non-transformed cells.
Research endpoints described above reflect published or model-based scientific observations and are not guaranteed outcomes. This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
Formula: C188H293N53O44S
Weight: 4032 g/mol
CAS: 1159861-00-3
PubChem CID: 16201774
Classification: Synthetic 32-residue peptide
Sequence: PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG
PHYSICAL PROPERTIES
Form: Lyophilized powder
Catalog strengths: 5 mg | 10 mg
Purity specification: ≥99% catalog specification; verify current batch COA
Storage: Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.
Testing: Batch documentation should be verified against the current lot before analytical use.
