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Thymosin Beta-4 (Full-Length / Timbetasin)

Price range: $70.00 through $110.00

Thymosin Beta-4 is a 43-amino-acid peptide and the most abundant member of the beta-thymosin family, distinguished by an N-terminally acetylated serine residue. It has the molecular formula C212H350N56O78S, a molecular weight of approximately 4963 g/mol, and CAS number 77591-33-4. Encoded by the TMSB4X gene, it was first isolated from calf thymus tissue in 1981. The peptide binds and sequesters G-actin monomers, regulating actin polymerization in eukaryotic cells. Supplied as a white to off-white lyophilized powder, soluble in water, stored refrigerated at 2–8 °C. This product is strictly for research purposes only.

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Certificate of Analysis

Independent laboratory testing confirms purity and composition of this research peptide.

99.230%
Purity
A2926079
Batch
August 2026
Date

View Certificate →

Overview

Thymosin Beta-4 is a 43-amino-acid peptide encoded by the TMSB4X gene and the most abundant member of the beta-thymosin family. It has the molecular formula C212H350N56O78S, a molecular weight of approximately 4963 g/mol, and CAS number 77591-33-4. The peptide was first isolated from calf thymus tissue in 1981 and has since been studied as a principal G-actin–sequestering protein in mammalian cells.

Structurally, Thymosin Beta-4 carries an N-terminal acetyl group on its serine residue. Its full sequence is Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser. The central LKKTETQ motif is the defining actin-binding domain and has been the focus of in-vitro biochemical characterization.

This product is strictly for research purposes only. Not approved for human or animal use.

PubChem Reference: View compound profile on NIH PubChem

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C212H350N56O78S

Weight: 4963 g/mol

CAS: 77591-33-4

Structure: 43 amino acid acetylated peptide

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Soluble in water

Purity: ≥98% (HPLC)

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

Additional information

Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Peptide

Thymosin β4 (full-length 43-aa; Timbetasin)

Strength

5mg, 10mg

CAS Number

77591-33-4

PubChem CID

16132341

Purity

≥99% (third-party HPLC and mass spectrometry verified)

Form

Lyophilized powder

Storage

Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.

Testing

Batch-specific COA included

Origin

Manufactured in the US

Purchase Option

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