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TB-500

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TB-500 is the synthetic form of Thymosin Beta-4, a 43-amino-acid peptide first isolated from calf thymus tissue in the 1960s. It has the molecular formula C212H350N56O78S, a molecular weight of 4,963.4 g/mol, and is identified by CAS number 77591-33-4. The peptide is notable for containing a central actin-binding domain — a region structurally complementary to actin, a major structural protein found in biology. Thymosin Beta-4 is classified as a naturally occurring intracellular peptide and is one of the most abundant members of the beta-thymosin family. TB-500 is supplied as a white to off-white lyophilized powder, soluble in water, and should be stored frozen for long-term stability. This product is strictly for research purposes only.

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Certificate of Analysis

Independent laboratory testing confirms purity and composition of this research peptide.

Endo Passed

99.110%
Purity
A2926031
Batch
August 2026
Date

View Certificate →

Overview

TB-500 is the synthetic form of Thymosin Beta-4, a 43-amino-acid peptide with the molecular formula C212H350N56O78S and a molecular weight of 4,963.4 g/mol. The naturally occurring version of this peptide was first isolated from calf thymus tissue in the 1960s during research into thymus gland extracts. TB-500 corresponds to the active region of the full Thymosin Beta-4 sequence.

Structurally, Thymosin Beta-4 is an unstructured, highly flexible peptide in solution, meaning it does not fold into a fixed three-dimensional shape the way many larger proteins do. It contains a central actin-binding domain — a stretch of amino acids structurally complementary to actin, one of the most common structural proteins in biology. The compound is identified by CAS number 77591-33-4 and appears as a white to off-white lyophilized powder that is soluble in water. It should be stored frozen for long-term stability.

This product is strictly for research purposes only.

PubChem Reference: View compound profile on NIH PubChem

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C212H350N56O78S

Weight: 4963.4 g/mol

CAS: 77591-33-4

Structure: 43 amino acid peptide

PHYSICAL PROPERTIES

Form: Lyophilized powder

Solubility: Water-soluble

Appearance: White to off-white powder

Storage: Store in freezer for long-term stability

Additional information

Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Peptide

TB-500 / Thymosin Beta-4

Strength

2mg, 5mg, 10mg

CAS Number

77591-33-4

PubChem CID

16132341

Purity

≥99% (third-party HPLC and mass spectrometry verified)

Form

Lyophilized powder

Storage

Store at −20°C (−4°F) for long-term storage or 4°C (39°F) for short-term storage; avoid repeated freeze-thaw cycles.

Testing

Batch-specific COA included

Origin

Manufactured in the US

Purchase Option

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