Certificate Reference
For continuity with the current catalog, this page links to laboratory documentation for a component or a closely related product. The linked certificate is a reference only and is not represented as the batch-specific COA for Vitamin B12.
Overview
Vitamin B12 (cobalamin) is an essential cobalt-containing cofactor with an unusually focused role in human metabolism: only two enzymes are known to depend directly on B12, methionine synthase in the cytosol and methylmalonyl-CoA mutase in mitochondria.
Research Reference: View compound profile on NIH PubChem
Research Focus
WHAT THIS FORMULA FEATURES
Those two reactions connect B12 to one-carbon/methylation chemistry and mitochondrial carbon metabolism. Methylcobalamin supports remethylation of homocysteine to methionine and formation of S-adenosylmethionine, while adenosylcobalamin supports conversion of methylmalonyl-CoA to succinyl-CoA.
EXPECTED RESEARCH READOUTS
Researchers commonly monitor methionine-synthase activity, homocysteine, methionine and SAM-related metabolites, methylmalonic acid, methylmalonyl-CoA-mutase activity, succinyl-CoA-related flux, DNA methylation-related endpoints, and cellular responses to controlled B12 depletion or repletion.
Research endpoints described above reflect published or model-based scientific observations and are not guaranteed outcomes. This product is strictly for research purposes only. Not approved for human or animal use.
Key Characteristics
MOLECULAR PROFILE
CAS: 68-19-9 | 13422-55-4
Classification: Cobalamin vitamin reference (form-dependent)
PHYSICAL PROPERTIES
Form: Liquid
Catalog strengths: 10 mL
Storage: Follow current supplier/COA instructions for this formulation.
